文章题目:CryoablationorDrugTherapyforInitialTreatmentofAtrialFibrillation
研究人员:JasonG.Andrade
发表时间：.01
期刊名称：NEnglJMed
影响因子：70.67
分区：1区
核心亮点
1、Inthistrialinvolvingpatientswithsymptomatic,paroxysmalatrialfibrillation,wefoundthatarrhythmiarecurredsignificantlylessoftenwithaninitialstrategyofcathetercryoballoonablationthanwithaninitialstrategyofantiarrhythmicdrugtherapy,withanumberneededtotreatof4.Theuseofimplantablerecordersthatwerecapableofcontinuousmonitoringalsoenabledthetrialtoshowthatablationresultedinalowerburdenofarrhythmia.在此项纳入有症状阵发性心房颤动患者的试验中，我们发现，初始治疗策略采用冷冻球囊导管消融术的情况下，心律失常复发率显著低于初始治疗策略采用抗心律失常药的情况；为了预防1例复发，需要治疗的人数为4。本试验使用了具有连续监测功能的植入式记录仪，因此本试验可以证明消融术组的心律失常负担较低。
2、Thecurrenttrialrestrictedcrossoverbetweenthegroups.Furthermore,continuousrhythmmonitoring,whichismoresensitiveindetectingparoxysmalatrialfibrillationthanintermittentmonitoring,wasused.Continuousmonitoringalsoallowsfortheassessmentofatrialfibrillationburden,whichmaybemorerelevanttopatientcenteredout
